5 interceptions leave Manning thinking long after loss to 49ers

New York Giants quarterback Eli Manning (10) reacts after failing to score on fourth down during the second half of an NFL football game against the San Francisco 49ers, Sunday, Nov. 16, 2014, in East Rutherford, N.J. (AP Photo/Bill Kostroun) (The Associated Press)

New York Giants quarterback Eli Manning (10) leaves the field after talking to San Francisco 49ers' Colin Kaepernick (7) after an NFL football game Sunday, Nov. 16, 2014, in East Rutherford, N.J. The 49ers won the game 16-10. (AP Photo/Julio Cortez) (The Associated Press)

EAST RUTHERFORD, N.J. – Sitting at home hours after tying his career-worst game with five interceptions, New York Giants quarterback Eli Manning couldn't avoid watching the video of the frustrating loss to the San Francisco 49ers.

Five interceptions in 45 passes, or one every nine throws. Five interceptions in a game that sent the Giants (3-7) to their fifth straight loss. Five interceptions in a 16-10 loss, including three on plays that started from the red zone.

It was akin to last season, when Manning threw a career-worst 27 interceptions. It was also out of character for this season. Coming into the game, Manning had thrown six picks all season in the new west coast offense.

Bad Eli returned at the worst time.