A veteran of George W. Bush's White House has kept Ohio's open U.S. Senate seat in the hands of the GOP.
Portman brushed aside criticism over close ties to Bush that include stints as White House budget director and U.S. trade ambassador.
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Democrats had been hoping the retirement of two-term Republican Sen. George Voinovich would give them a good chance at gaining a GOP seat.
But Fisher's campaign sputtered after the state's Democratic primary and couldn't match Portman's fundraising machine.