Will Fred Savage be Kelly Ripa's new 'Live!' co-host?

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Fred Savage is feeling "very comfortable" on the "Live! With Kelly" stage.

The 40-year-old actor was Kelly Ripa's "Live!" co-host on Wednesday, when the two displayed their obvious chemistry. Ripa greeted Savage -- who has successfully co-hosted "Live!" before -- with a "welcome home," to which he tellingly replied, "I feel very comfortable now."

He also made it clear he enjoys the gig, when the former "Wonder Years" star told a story about what his young daughter Lily bought him for his recent 40th birthday. Savage said that when the salesman asked what her dad likes, she adorably replied, "Well, he really likes co-hosting with Kelly."

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Earlier this month, a source told ET that Savage is definitely interested in becoming Ripa's permanent "Live!" co-host, though he's reluctant to relocate his wife, Jennifer, and their three young kids -- Oliver, Lily, and Auggie -- to New York City. Savage is booked to co-host the show for the rest of the week.

Savage was a natural on "Live!" on Wednesday, interviewing both Blake Lively and "Mr. Robot" star Rami Malek.

He also gamely ate stinky tofu during a "Bizarre Foods" segment with Andrew Zimmern.

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Though when ET spoke with Ripa's good friend, Andy Cohen, at Sunday's MLB All-Star Legends and Celebrity Softball Game at Petco Park in San Diego, California, the "Real Housewives" executive producer said he was still pulling for Anderson Cooper.

"You know, the cool thing about this is, Kelly's 'The Bachelorette,' and she keeps getting to date these guys on TV and see who she clicks with -- it's awesome," he joked. "Actually, it's a more lasting marriage than any marriage that has come out of 'The Bachelor,' if you think about it."

Ripa's "Live!" co-host will be announced before the new season starts in September.