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You talkin' to me?

You talkin' to me?

That's the question Robert DeNiro is going to be asking Martin Scorcese once again when the latter directs the former for the first time since 1995's "Casino."

Scorcese confirmed the two would film "The Irishman" together while speaking at a BAFTA ceremony, Digital Spy reported.

The movie is based on the novel "I Heard You Pain Houses" about the true-life story of union boss turned mobster Frank "The Irishman" Sheeran.

Filming is scheduled to begin in 2011.

De Niro and Scorsese first worked together on 1973's "Mean Streets." They went on to become one of Hollywood's most successful and prolific director/actor combinations, churning out "Taxi Driver," "New York, New York,"" Raging Bull," "The King Of Comedy," "Goodfellas," "Cape Fear," and "Casino" over the next 20 years.

DeNiro won two Oscars, including one in Scorcese's "Raging Bull" about prize fighter Jake LaMotta.

Scorcese, while nominated several times for his work with DeNiro, won his Oscar for "The Departed," starring Leonardo DiCaprio and Jack Nicholson, in 2007.