"Grey's Anatomy" is losing one of its core cast members.

Sandra Oh, who’s played Dr. Christina Yang since the show’s 2005 debut, will leave after the upcoming (10th) season of the soapy ABC hospital drama.

“Creatively, I really feel like I gave it my all, and I feel ready to let her go,” Oh told the Hollywood Reporter, which broke the news.

“It’s such an interesting thing to play a character for so long and to actually get the sense that she wants to be let go as well.

“[Christina] wants to be let go, and I am ready to let her go.”

ABC renewed “Grey’s Anatomy” for a 10th season, but the show’s future beyond that remains undecided. The contracts of core cast members Patrick Dempsey (Derek “McDreamy” Shepherd), Ellen Pompeo (Meredith), Justin Chambers (Alex), James Pickens Jr. (Webber) and Chandra Wilson (Bailey) all expire at the end of the upcoming season, according to the report.

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