AZ Alkmaar's convincing 3-1 win at Venlo on Sunday allowed the club to move four points clear at the top of the Eredivisie table.
Rasmus Elm's sixth goal of the season came in the 32nd minute to put AZ in front, while Adam Maher scored the club's second goal just after the hour mark.
Simon Poulsen tallied a third goal for the visitors to ensure a seventh win in eight games to start the season, while Venlo got a late consolation goal from Robert Cullen to spoil the clean sheet.
Groningen 1, Ajax 0
Groningen, Netherlands - Ajax suffered its first defeat of the season on Sunday, losing 1-0 at Groningen.
The decisive sequence in the match came just after the hour mark as Ajax defender Gregory Van Der Wiel was shown a red card after a foul inside the penalty area, allowing Groningen's Leandro Bacuna to convert from the spot to put his team in the lead.
Groningen held out over the final 30 minutes with a man advantage to move into eighth place, while Ajax drops six points back of leaders AZ Alkmaar.
Den Haag 3, Feyenoord 0
Rotterdam, Netherlands - Feyenoord was dealt a 3-0 home defeat by Den Haag on Sunday, dropping the club further off the pace at the top of the table.
John Verhoek was on target for the visitors after 15 minutes and the lead was doubled just before halftime through Wesley Verhoek before Tjaronn Chery put the result away with a goal early in the second half.
Twente 2, Excelsior 2
Enschede, Netherlands - A goal from Luuk de Jong in the 89th minute prevented Twente from suffering a home defeat to last-place Excelsior on Sunday.
Ola John's goal put Twente in front at halftime, but Darren Maatsen popped up to score goals in the 84th and 85th minutes to give the visitors a stunning advantage, with De Jong's goal saving their blushes.
Twente is four points behind leaders AZ Alkmaar with the result while Excelsior claimed just its second point of the campaign in eight games.
PSV Eindhoven 2, NEC 0
Nijmegen, Netherlands - PSV Eindhoven moved into second place after tallying two late goals in a 2-0 win over NEC on Sunday.
The match remained scoreless until the 84th minute when Zakaria Labyad broke the deadlock for PSV, while Tim Matavz tallied a second goal two minutes later to secure all three points for PSV, which is four back of leaders AZ Alkmaar.
NEC has lost five of its first eight games to slip to 15th in the league table.