The U.S. Central Command said Monday in a statement the strike occurred near the northern province of Aleppo.
The British-based Syrian Observatory for Human Rights, an opposition-linked war monitor, said Monday the strike killed eight members of the Al Qaeda-linked Horas al-Din, which is Arabic for “Guardians of Religion.”
The Observatory said the dead included six commanders: two Algerians, two Tunisians, an Egyptian and a Syrian.
Al Qaeda-linked militants control wide swaths of northern Syria, mostly in Idlib province, the last major rebel stronghold in the war-torn country.
U.S. military officials said northern Syria remains a “safe haven” for Al Qaeda leaders actively coordinating terrorist attacks.
“With our allies and partners, we will continue to target [ISIS] and Al Qaeda to prevent both groups from using Syria as a safe haven,” the statement said.
It’s been more than two years since the U.S. military struck al Qaeda fighters inside Syria.
The last known strike was launched in mid-March 2017 in northwest Syria’s Aleppo Province killing dozens of fighters, days before the U.S. military launched cruise missiles targeting an airfield in Syria linked to a chemical weapons attack the Trump administration blamed on Syria President Bashar al-Assad.
Fox News' Lucas Tomlinson and the Associated Press contributed to this report.