Emergency services say two people have been killed and an unknown number injured in a pileup at least 150 cars and trucks on a Dutch highway shrouded in thick mist.

The Zeeland Security Region said in a statement that the series of crashes happened early Tuesday on the A58 highway in the southern province of Zeeland.

The highway was closed in both directions as a result.

Authorities appealed to tourists to avoid the popular coastal region as emergency services treated the injured and worked to remove damaged vehicles.