Our exclusive guests this week:
• Homeland Security Secretary Janet Napolitano
• Health and Human Services Secretary Kathleen Sebelius
• Dr. Richard Besser, Acting Director of the Centers for Disease Control and Prevention.
• Senate Majority Whip Dick Durbin, D-Ill.
• Sen. John Ensign, R-Nev., Republican Policy Committee chair

The United States government has declared a public health emergency in the U.S. over the outbreak of swine flu. Also, this week the World Health Organization raised the worldwide pandemic alert level to phase 5, signaling a pandemic is imminent, as new cases continue to mount. How serious is the outbreak and what’s being done to contain it? We’ll get the latest from the nation’s top health officials – Homeland Security Secretary Janet Napolitano, Health and Human Services Secretary Kathleen Sebelius, and Acting Director of the Centers for Disease Control, Dr. Richard Besser.

Meanwhile, Senator Arlen Specter of Pennsylvania gave a boost to Senate Democrats this week when he left the Republican Party and became a Democrat. Specter’s defection puts Democrats within one vote of a 60 seat filibuster-proof majority, as one seat remains undecided in the Minnesota race between incumbent Senator Norm Colman and Democrat Al Franken. What does this mean for President Obama’s agenda and the GOP? We’ll talk with two Senate leaders, Democrat Majority Whip Dick Durbin and Republican Policy Committee Chairman John Ensign.

Then, Supreme Court Justice David Souter plans to retire. What happens to the balance of power on the curt? We’ll discuss with our Sunday panel: Radio talk show host Laura Ingraham, Mara Liasson of National Public Radio, Bill Kristol of the Weekly Standard and Juan Williams of National Public Radio.

Plus, our Power Player of the Week, Christopher Buckley, the only child of Pat and William F. Buckley discusses life growing up with his iconic father and mother.

So check your local listings and we’ll see you on the next "FOX News Sunday."