50 says he disagrees with West's infamous statement that " George Bush doesn't care about black people," proclaimed during a September telethon for Hurricane Katrina victims.
"I think people responded to it the best way they can," 50 told ContactMusic.com. "What Kanye West was saying, I don't know where that came from."
Instead, 50 said, "The New Orleans disaster was meant to happen. It was an act of God."
It wouldn't be the first time 50 Cent, whose real name is Curtis Jackson, made comments that weren't flattering of West. In a September interview with MTV, 50 — while otherwise complimentary of the popular "Gold Digger" rapper — said: "I feel like Kanye West is successful because of me."
"After 50 Cent, (hip-hop fans) was looking for something non-confrontational, and they went after first thing that came along. That was Kanye West, and his record took off."
West's second album, "Late Registration," has remained near the top of the charts since debuting Aug. 30.
50 stars in the upcoming film "Get Rich or Die Tryin," a biopic of the rapper that is set to open Nov. 9.