Ponder rolled out to his right on a first-down play and was driven to the turf by Bears' defensive end Israel Idonije. Ponder got up and walked off the field with help. He was carted to the locker room once on the sideline and his return is questionable.
Ponder was also injured in last week's win over the Washington Redskins when he suffered a concussion.
He completed 4-of-10 passes for 28 yards and interception before leaving and was replaced by Joe Webb under center.