Minnesota Twins designated hitter Jim Thome hit game series against the Detroit Tigers at Comerica Park.

The blast came in the seventh inning off Tigers left-handed reliever Daniel Schlereth, an opposite-field, three-run shot which barely cleared the wall in left field. It gave the Twins a 9-5 advantage.

He becomes the eighth player in baseball history to reach the milestone, and the first since Yankees third baseman Alex Rodriguez last season.

Thome entered play with 598 career homers, and hit his first of the contest -- a two-run blast to left -- in the sixth inning off Rick Porcello.