The Bears (2-0) grabbed a 17-0 halftime lead and withstood a big push a week after rallying from 17 down at Detroit for their first season-opening win in seven years.
The Giants (0-2) refused to go quietly even though they lost star running back Saquon Barkley to a right knee injury on the opening play of the second quarter.
New York’s Dion Lewis made it a seven-point game when he plowed in from the 1 in the opening minute of the fourth.
James Bradberry then intercepted Trubisky when he ripped the ball out of Allen Robinson’s hands, leading to a 37-yard field goal by Graham Gano that cut it to 17-13 with 7:43 remaining.
The Bears caught a big break on fourth down at the New York 36 with just under four minutes left. New York’s Blake Martinez deflected a pass intended for Jimmy Graham, and the ball ricocheted to tackle Bobby Massie for a first down. Cairo Santos missed wide left on a 50-yard field goal attempt, giving New York the ball on the 40 with 2:02 remaining.
The Giants drove to the 10 before Golden Tate got flagged for pushing off against Eddie Jackson near the goal line on an incomplete pass as time expired.
Trubisky completed 18 of 28 passes for 190 yards and was intercepted twice.
He threw a 28-yard touchdown pass to David Montgomery on the game’s opening possession and fired a 15-yarder to Darnell Mooney in the closing seconds of the first half to give the Bears a 17-0 lead.
Montgomery ran for 82 yards. Robert Quinn had a strip sack in the first quarter that led to a field goal in his Bears debut after missing the opener with an ankle injury. Khalil Mack had his first sack of the season and recovered a fumble for Chicago.
Limited to 6 yards on 15 attempts against Pittsburgh on Monday night, Barkley came up clutching his right knee when he was dragged down by Jackson at the end of a run. The 2018 offensive rookie of the year was taken for X-rays after being helped to the sideline and will be examined further on Monday.
Daniel Jones threw for 241 yards and an interception. Giants coach Joe Judge is still looking for his first win.
The Bears announced a three-year contract extension with running back and return specialist Tarik Cohen on Sunday. The deal guarantees about $9.5 million and could be worth $18.25 million, agent Drew Rosenhaus said.
Giants: WR Sterling Shepard left with a toe injury.
Bears: Montgomery hurt his neck early in the second quarter when he went airborne over Austin Johnson on a short run and landed head-first. He returned in the second half.
Giants: Host San Francisco next Sunday.
Bears: Visit Atlanta next Sunday.