Updated

HOUSTON (2-2) at SAN FRANCISCO (2-2)

Sunday, 8:30 p.m. ET, NBC

OPENING LINE — 49ers by 6 1/2

RECORD VS. SPREAD — Houston 0-4, San Francisco 2-2

SERIES RECORD — Tied 1-1

LAST MEETING — Texans beat 49ers 24-21, Oct. 25, 2009

LAST WEEK — Texans lost to Seahawks 23-20 (OT); 49ers beat Rams, 35-11

AP PRO32 RANKING — Texans No. 12, 49ers No. 7

TEXANS OFFENSE — OVERALL (5), RUSH (7), PASS (9)

TEXANS DEFENSE — OVERALL (1), RUSH (23), PASS (1)

49ERS OFFENSE — OVERALL (21), RUSH (8), PASS (27)

49ERS DEFENSE — OVERALL (4), RUSH (19), PASS (3)

STREAKS, STATS AND NOTES — Home team has won each of previous two meetings, both by three points. ... 49ers have dropped last two Sunday night games, both at Seattle. Houston has lost its last two games. ... Houston holding opponents to 254.3 yards per game, to 299.8 by San Francisco's D. ... Texans are only NFL team with top-five offense and defense. ... Texans TE Owen Daniels has at least one catch in 87 straight regular-season games. Will play in 100th career game, all with Houston, for fourth most in franchise history. ...Texans lost LB Brian Cushing to concussion vs. Seahawks and his status was unclear. ... Houston WR Andre Johnson tied for NFL lead with 34 receptions, team-best 368 yards and averaging 10.8 yards per catch. ... Texans RB Arian Foster leads AFC with 292 yards rushing. ... Johnson looks to extend franchise-record games played to 143. ... 49ers playing third straight prime time game. ... Since 2011, 49ers are 9-0 when Frank Gore runs for 100 yards, as he did last week in win vs. Rams (153). ... 49ers LB NaVorro Bowman had two of San Francisco's five sacks at St. Louis. ... 49ers TE Vernon Davis had first career three-touchdown game vs. Texans in last meeting. ... In four career matchups with Houston, DE Justin Smith has 21 tackles, 2 1/2 sacks and forced fumble. ...49ers LB Patrick Willis is expected back after he missed game with Rams (strained groin).

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AP NFL website: www.pro32.ap.org