C.J. Fair added 16 points on 6-for-6 shooting for the Orange (15-0, 2-0 Big East), who have won by double figures 12 times this year. Dion Waiters tallied 13 points.
Cleveland Melvin ended with 23 points and eight rebounds for the Blue Demons (9-4, 0-1), who had a five-game winning streak snapped. Donnavan Kirk added 14 points.