Once-promising American Melanie Oudin suffered a first-round loss Monday at the $740,000 Family Circle Cup.

Tenth-seeded Spaniard Anabel Medina Garrigues grounded the 20-year-old Oudin 6-4, 4-6, 6-0 on the green clay at Family Circle Tennis Center. The Georgia native Oudin is best known for her Cinderella run into the U.S. Open quarterfinals in 2009.

Meanwhile, 14th-seeded Slovenian Polona Hercog humbled 41-year-old Japanese Kimiko Date-Krumm 6-4, 6-3 and Argentine qualifier Paula Ormaechea upended 15th-seeded South African Chanelle Scheepers 6-1, 1-6, 6-4.

Kazakhstan's Galina Voskoboeva beat former top-10 performer Jelena Dokic, 4-3, as the Aussie veteran retired with a right wrist injury.

Former No. 1 Caroline Wozniacki, who is not defending her title here this week, beat Russian Elena Vesnina in last year's Family Circle final. Vesnina advanced Monday with a hard-fought 7-6 (12-10), 7-5 victory over Canadian Stephanie Dubois.

Additional Day-1 wins came for Russian Vera Dushevina, Greek Eleni Daniilidou, Ukrainian Kateryna Bondarenko, Croat Mirjana Lucic, and Czechs Lucie Hradecka and Barbora Zahlavova Strycova.

The top seed here, Agnieszka Radwanska, pulled out of the event on Sunday after beating former world No. 1 Maria Sharapova in Saturday's title match in Miami. The top seeds now are second-seeded U.S. Open champ Samantha Stosur and former Wimbledon runner-up Marion Bartoli. Stosur was the Charleston champion two years ago.

The field of 56 here also includes a fifth-seeded Serena Williams and an unseeded Venus Williams. Serena titled here in 2008 and was the runner-up in 2003, while Venus was the 2004 champ.

This week's titlist will claim $115,000.