Second-seeded Ekaterina Makarova has withdrawn from the Family Circle Cup with a stomach illness only hours after winning her opening match Wednesday.

Makarova felt stomach pain during her 5-7, 6-3, 6-2 win over China's Zhang Shuai and saw trainers after the match. She said in a statement she and her team feel it's best to get healthy for the remainder of the clay-court season.

The WTA cited gastrointestinal illness as Makarova's reason for leaving.

Makarova's depature means 13th-seeded Irina-Camelia Begu, the 26-year-old Russian's next opponent, will advance to Friday's quarterfinals.

Makarova is ranked eighth in the world and among just two top-10 players competing in the clay-court tournament.

Top-seeded Eugenie Bouchard is scheduled to play later Wednesday.