Reigning champion and two-time winner Andy Murray and four-time titlist Andy Roddick were a pair of second-round upset victims at the hands of Frenchmen Wednesday at the $785,000 Aegon Championships, a grass-court Wimbledon tune-up.

The top-seeded Murray was knocked out by Nicolas Mahut 6-3, 6-7 (4-7), 7-6 (7-1), while the seventh-seeded Roddick succumbed to Edouard Roger-Vasselin 6-4, 4-6, 7-5 at The Queen's Club. Mahut swatted 13 aces past Murray in their 2-hour, 35-minute affair, while Roddick crushed 22 aces in a losing effort against Roger-Vasselin, who popped 13 aces himself on Day 3.

Mahut was the 2007 Queen's Club runner-up.

The struggling former No. 1 Roddick has now lost his last six matches on tour and hasn't reached a quarterfinal since the first week of March.

The three-time Grand Slam runner-up Murray beat France's Jo-Wilfried Tsonga in last year's Queen's Club finale.

Murray and Roddick each received byes into the second round this week.

A second-seeded Tsonga avoided an upset by handling British wild card Jamie Baker 6-3, 6-2, while another upset came when Italian Simone Bolelli overcame fourth-seeded Frenchman Gilles Simon 4-6, 6-3, 7-6 (7-2).

Third seed Janko Tipsarevic of Serbia managed to move on with a 6-1, 7-6 (7-2) victory over American lucky-loser Ryan Sweeting.

Five other top-10 seeds moved into the third round, as No. 5 Feliciano Lopez of Spain beat Belgian Steve Darcis 6-3, 3-6, 7-5; No. 6 Croat Marin Cilic drubbed Aussie Matthew Ebden 6-2, 6-1; No. 8 Frenchman Julien Benneteau outlasted Japan's Tatsuma Ito 5-7, 6-4, 7-5; No. 9 South African Kevin Anderson got past Ukrainian Sergiy Stakhovsky 7-6 (7-5), 2-6, 3-4, retired; and No. 10 Argentine David Nalbandian dismissed Belgian qualifier Ruben Bemelmans 6-4, 6-2.

Six more upsets came when Czech Lukas Rosol took out 11th-seeded Cypriot Marcos Baghdatis 6-3, 4-6, 6-4; American Sam Querrey, the 2010 Queen's Club champ, defeated 12th-seeded Uzbekistanian Denis Istomin 7-6 (7-4), 6-3; Belgian Xavier Malisse erased 13th-seeded Russian Alex Bogomolov Jr. 6-3, 4-6, 6-0; Bulgarian Grigor Dimitrov tackled 14th-seeded Luxembourger Gilles Muller 7-6 (7-1), 6-4; Croat Ivan Dodig drove out 15th-seeded Japanese Go Soeda 6-3, 7-6 (7-3); and Taiwanese Yen-Hsun Lu topped 16th-seeded 6-foot-10 Croat Ivo Karlovic 6-7 (3-7), 7-6 (8-6), 7-6 (9-7). The massive-serving 2005 Queen's Club runner-up Karlovic was shown the door despite a 35-ace effort. Neither Karlovic nor Lu were able to break serve on Day 3.

The aforementioned Ito had to complete his opening-round match on Wednesday, which he did by getting past Italian Paolo Lorenzi 7-6 (8-6), 4-6, 6-2.

In some third-round action on Thursday, Tsonga will battle Dodig, Tipsarevic will tangle with Lu and the former Wimbledon runner-up Nalbandian will be opposed by Roger-Vasselin.