A 2-1 loss at Chelsea on Monday has left the Citizens licking their wounds, but City boss Roberto Mancini believes that his side has what it takes to bounce back against the Gunners.
"I think that at these moments we should be strong," said Mancini. "After one defeat, we can improve - we know what we can do, and in this moment we can become stronger."
Mancini acknowledged that Arsenal is in good form at the moment, but revealed that picking up three points takes precedence to simply playing well.
"We play Arsenal on Sunday and at the moment Arsenal are playing very well," Mancini said. "It will be difficult but we need to start again. What is important is that we start to win again."
By its usual high standards, Arsenal started the new campaign in relatively slow fashion but has come on strong of late. The Gunners are unbeaten in their last eight Premiership matches and finished top of their group in the Champions League.
Arsene Wenger's men have risen to fifth in the Premier League table with 29 points through 15 games, nine points behind league-leaders Manchester City.
City's lead in England's top flight dwindled to just two points after Manchester United made up some ground on the Citizens with a 4-1 drubbing of Wolverhampton its last time out. United travels to Loftus Road to face QPR on Sunday.
In its last outing, Tottenham dropped its first league game since August, snapping an 11-game unbeaten run. On Sunday, Spurs host Sunderland as the Black Cats are fresh off of their 2-1 defeat of Blackburn.
And in Sunday's other match, ninth-place Aston Villa hosts sixth-place Liverpool at Villa Park with a win set to bring the Villains to within four points of the Anfield outfit.
Stoke City is on an impressive run at the moment. The Potters have won three- straight in the Premier League in addition to advancing to the knockout round of the Europa League. Wolves have the dubious task of halting the in-form Potters as the two sides meet at Molineux on Saturday.
After opening the new season with an 11-game unbeaten run, Newcastle United has now fallen into a bit of rut, failing to pick up a win in its last four league games. Granted, the Magpies have faced Manchester United, Manchester City, and Chelsea over that winless stretch, but they came away disappointed after a humbling 4-2 defeat at the hands of Norwich City last weekend.
Newcastle looks to regain some of its early-season form as it hosts Swansea City at St. James' Park.
Finally, Chelsea, with three-straight wins in the Premier League, heads to the DW Stadium to face Wigan. The Lactics have climbed out of the cellar after winning two of their last three, but still sit third-from-bottom with 12 points.
Also on Saturday, second-from-bottom Blackburn hosts West Bromwich at Ewood Park, Norwich City hopes to hand Everton its third-straight loss when they square off at Goodison Park, and Fulham tries to rebound after falling to Swansea City as the Cottagers host last-place Bolton at Craven Cottage.