Tampa, FL – Steven Stamkos had two goals and an assist and 1, to sweep a and-home series.
The Lightning won Friday's opener, 2-1, on Stamkos overtime goal to halt a two-game skid.
Martin St. Louis, Tom Pyatt and Ryan Malone also scored in Saturday's victory.
Shawn Matthias had a late goal for the Panthers, who had won three straight before encountering the Lightning.
Jacob Markstrom stopped 29 shots in the loss.