Murphy has a strained left groin, although an MRI shows no tear. Manager Ron Washington says Murphy will be held out of the four-game series against the Los Angeles Angels that will wrap up the regular season, and he should be ready to play next week.
Hamilton's been out since breaking two ribs Sept. 4 while crashing into an outfield wall making a catch at Minnesota. He's scheduled to play six innings in the outfield Friday night. Plans are for him to be designated hitter Saturday and play the outfield again Sunday.
Hamilton leads the majors with a .361 batting average.