The Flyers overcame a three-goal deficit to spoil the debut of Anaheim's new head coach Bruce Boudreau. He was fired as the head coach of the Washington Capitals on Monday and quickly hired by Anaheim early Thursday morning.
Jaromir Jagr had two goals and an assist for the Flyers, winners in three of their last four games.
Ilya Bryzgalov stopped 19-of-22 shots to earn the win.
Jonas Hiller allowed all four goals on 47 shots.