The Steelmen enter the match three points clear of Celtic with one more game played. But despite an inconsistent start to the league season for the Glasgow side, manager Neil Lennon was encouraged by his team's 3-1 win over Rennes in the Europa League on Thursday.
"We put out a strong team last night and got a great performance from them and I'm hoping for more of the same now on Sunday," Lennon said.
"The next couple of days are important in recovery and trying to keep them as fresh as possible but they should be feeling good about themselves after last night."
Celtic has claimed only one win from its last four league matches to fall 12 points back of leaders Rangers, but the Hoops must first get back into the win column consistently if they want any chance at tracking down their rivals.
Motherwell brings a five-game unbeaten streak into the match and will try to prevent Celtic from claiming its first away win in four games.
Rangers has won 11 of its last 12 matches and entertains Dundee United, which got back into the win column last weekend with a 4-1 triumph over Dunfermline, while Hearts tries to bounce back from home defeats to Rangers and Kilmarnock with a win at St Mirren.
Inverness sits on the bottom of the league and will be searching for its first away win of the campaign at Kilmarnock, Hibernian hosts a Dunfermline side that is winless in eight matches and the weekend concludes on Monday when Aberdeen visits St Johnstone, which will be run by new manager Steve Lomas for the first time.