Buffalo, NY – Reggie Bush carried the ball 25 times for 203 23, in Todd Bowles' first game as interim head coach.
Bush's 203 rushing yards was the most by a Dolphin since Ricky Williams had 216 against the Bears on December 9, 2002.
Tony Sparano was fired on Monday after leading the team to a 4-9 start. Bowles was promoted from his position as secondary coach.
Matt Moore completed 10-of-20 passes for 217 yards and two touchdowns for the Dolphins (5-9), who have won five of seven since an 0-7 start.
Ryan Fitzpatrick completed 31-of-47 passes for 316 yards, two touchdowns and three interceptions for the Bills (5-9), who have lost seven in a row.
C.J. Spiller carried the ball 12 times for 91 yards and a score. He also caught nine passes for 76 yards and a touchdown.