The Blues have won four in a row for the second time this season and are now 12-2-3 since head coach Ken Hitchcock took over for the fired Davis Payne.
Meanwhile, Nashville is on its longest winning streak of the year and tonight the Predators will aim for their first five-game tear since posting six consecutive wins from March 17-26 of last season.
St. Louis and the Preds met once earlier this season on Oct. 8, when Nashville notched a 4-2 road victory to end a three-game slide in the series. The Blues have won the last two encounters in Tennessee.
The Blues went 4-1 on their recent five-game homestand and the club will play three of its next four games on the road, where St. Louis has a 6-6-2 record this season compared to a 12-3-1 mark in the Gateway City.
St. Louis earned its most recent victory Thursday against the New York Rangers, as Alexander Steen had a goal and an assist to help lift the Blues to a 4-1 decision.
"We've found a rhythm," Steen said. "Everybody's supporting each other and pulling on the rope."
David Perron, Jason Arnott and Patrik Berglund also lit the lamp for the Blues, who are tied with Detroit for second place in the Central Division. Brian Elliott made 25 saves for St. Louis, improving his record to 13-2-0 on the season.
Nashville is 3-0 so far on a four-game homestand that ends tonight and the Preds are sporting a 7-5-3 record at Bridgestone Arena this season.
The Predators earned their latest victory Thursday against Detroit, as star defenseman Shea Weber scored the tying and go-ahead goals late in the third period to help lift Nashville to the 4-3 victory. Weber's game-winner came with 1:36 left in the third and was his sixth tally of the season.
"In big moments you need your top players to step up and Shea stepped up in a huge way today," said Predators coach Barry Trotz.
Nashville will play its next game in Washington on Tuesday before returning to Music City for home tests against the Red Wings and Blues.