McGee was hurt during the second quarter of Buffalo's 35-8 loss while trying to defend a touchdown pass to Miami's Davone Bess.
McGee will have his season shortened for the third time in as many years because of injury. A shoulder issue kept him out for much of the second half in 2009 sent him to injured reserve in late December, while a knee procedure last year allowed him to play just nine games.
A hamstring injury suffered in the season-opener this year kept him out for a month before he returned in October.
McGee is in his ninth NFL season, all with the Bills, and his 17 career interceptions tie him for 15th in team history. He has seven career return touchdowns, including five on kickoffs.