The Colts had lost their first 13 games before beating the Titans, 27-13, on Sunday. It was their first win without Manning under center since December 14, 1997.
Manning has been out all season with a lingering neck injury but remained on the active roster and was cleared for workouts of greater intensity earlier this month.
Colts vice chairman Bill Polian made it clear after Sunday's win that despite the four-time MVP making strides in his recovery, he will continue to remain sidelined.
"His rehabilitation has not come far enough to make it prudent for him to step on the field in game action. He may practice in some very scripted and circumscribed circumstances if he wishes, that is entirely up to him," Polian said.
Manning has endured three surgeries on his neck, including two in the past five months. He had a single level anterior fusion surgery on September 8 and was cleared to leave the booth and stand on the sidelines in early October.