Rev. Jesse Jackson, one of the most prominent civil rights leaders in American history, is stepping down as leader of the organization he founded in 1971.

A spokesperson for Rep. Jonathan Jackson, Jesse Jackson's son, confirmed the longtime civil rights leader will be retiring this year as leader of the Rainbow PUSH Coalition.

The elder Jackson, a civil rights leader and two-time presidential candidate, plans to announce his decision on Sunday during the organization’s annual convention, Rep. Jackson told the Chicago Sun-Times.

Jonathan Jackson, an Illinois Democrat, said his father "has forever been on the scene of justice and has never stopped fighting for civil rights" and that will be "his mark upon history."

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Jessie Jackson

Rev. Jesse Jackson speaks during a news conference after the verdict was read in the trial of former Minneapolis police officer Derek Chauvin. (AP Newsroom)

Rev. Jackson, who will turn 82 in October, has remained active in civil rights in recent years despite health setbacks.

He announced in 2017 that he was receiving treatment for Parkinson's disease and had gallbladder surgery in 2021. Later in 2021, Jackson said he was receiving treatment for COVID-19, which required time at a physical therapy facility.

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Jesse Jackson in 1991

Rev. Jesse Jackson marches in an anti-war demonstration in Washington, D.C., on Jan. 15, 1991. (Mark Reinstein/Corbis via Getty Images)

In November 2021, Jackson was hospitalized for a head injury stemming from a fall.

Jackson, a protégé of the Rev. Martin Luther King, broke with the Southern Christian Leadership Conference in 1971 to form Operation PUSH — originally named People United to Save Humanity — a sweeping civil rights organization based in Chicago’s South Side.

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Jesse Jackson

Rev. Jesse L. Jackson attends the 2nd Annual Attorney Benjamin Crump Equal Justice Now Awards at Courtyard by Marriott Los Angeles LAX/Century Boulevard in Los Angeles on June 10, 2022. (Unique Nicole/Getty Images)

The organization was later renamed the Rainbow PUSH Coalition, with a mission ranging from encouraging corporations to hire more minorities to voter registration drives in minority communities. Its annual convention is set for this weekend in Chicago.

Jackson was the most successful Black candidate for the U.S. presidency before Barack Obama's run in 2008. Jackson won 13 primaries and caucuses for the Democratic nomination in 1988.

"Reverend Jesse Jackson is officially pivoting from his role as president of Rainbow PUSH Coalition," the Rainbow PUSH Coalition said in a statement to Fox News Digital. 

"His commitment is unwavering, and he will elevate his life’s work by teaching ministers how to fight for social justice and continue the freedom movement. Rev. Jackson’s global impact and civil rights career will be celebrated this weekend at the 57th annual Rainbow PUSH Coalition convention, where his successor will be introduced."

The Associated Press contributed to this report.