A study of the popular anti-wrinkle drug Botox, which was recently licensed as a treatment for migraines, shows the drug does not have a significant effect against headaches, Agence France-Presse reported.

Botox works by paralyzing select muscles on the face that cause wrinkles. The United States, Britain and several other countries have authorized the drug for injections to 39 sites in the head and neck muscles in hopes to relieve migraines.

The results of the study, published in the British journal “Drug and Therapeutics Bulletin” said there was very “limited evidence of benefit.”

Between one and 10 percent of those injected not only had no migraine relief, but instead reported muscle spasms, rashes and itches.

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