BenJarvus Green-Ellis rushed for a career-high 21 decision over the New York Jets in an AFC East divisional clash.
Tom Brady completed 24-of-33 passes for 321 yards and a touchdown with an interception for the Patriots (4-1). Wes Welker caught five passes for 136 yards.
Mark Sanchez tallied 166 yards and two touchdowns on 16-of-26 passes in a losing effort for New York (2-3).
Shonn Greene carried the ball 21 times for 83 yards and a score, while Santonio Holmes and Jeremy Kerley each caught TD passes.