The Rams took quarterback Sam Bradford with the No. 1 pick on Thursday, and moved to protect that investment by taking Saffold with the 33rd overall selection Friday night.
The 6-4, 312-pound Saffold started 41 games in his college career and was a second-team All-Big Ten pick as a senior.
During his tenure in the lineup, the Hoosiers had 29 100-yard games.
The Rams hung onto the pick despite widespread rumors they would be willing to trade down. They've been dissatisfied with incumbent left tackle Alex Barron.
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