Ryan Mathews rushed for 57 yards and a touchdown in a half of play and the San Diego Chargers beat mistake-prone Arizona 24-7 Saturday night for their first preseason victory under new coach Mike McCoy.
The Chargers blocked a punt, blocked a field goal and returned a fumble for a touchdown.
The Cardinals lost several players due to injury, including left guard Jonathan Cooper, the team's first-round pick who put no weight on his left ankle as he was helped off the field in the third quarter.
Arizona's Rashard Mendenhall carried six times for 47 yards before leaving with an ankle injury.
Philip Rivers completed 10 of 18 passes for 71 yards with an interception. Arizona's Carson Palmer was 12 of 23 for 122 yards and a TD.
AP NFL website: www.pro32.ap.org