C.J. Fair led five Syracuse players in double figures with 16 points and grabbed a career-high 13 rebounds, as the fourth- ranked Orange beat Long Beach State, 84-53.
Michael Carter-Williams had a 15-point, 10-assist double-double for the Orange (7-0), who have won their last 27 games at the Carrier Dome, the longest home winning streak in Division I.
Rakeem Christmas, Trevor Cooney and Brandon Triche each scored 11 points in the 897th win of coach Jim Boeheim's career.
Dan Jennings paced the 49ers (3-5) with a career-high 20 points.
Syracuse took control right from the opening tip, building a 14-4 lead just past the five-minute mark.
The 49ers managed to trim their deficit to 25-19 when Peter Pappageorge hit a 3-pointer with 7:32 remaining, but consecutive dunks from Christmas made it 42-26.
Syracuse stretched its lead to 49-27 on a Carter-Williams trey before entering the break up by 20.
The outcome was never in doubt as the Orange's advantage grew to as many as 34 in the second half.
Syracuse has won 49 straight non-conference games in the regular season ... DaJuan Coleman had nine rebounds and three blocks for the Orange ... Pappageorge compiled 11 points and six assists ... Long Beach State was held to 29.2 percent shooting.