Investigators say they've arrested two men on murder charges in a human trafficking case involving the death of a 14-year-old girl in Orlando.

Detective Michael Fields told reporters Wednesday that 19-year-old Avorice Jeno Holman and 22-year-old Jose Ignacia Santiago-Sotomayor were being held without bond.

Authorities are searching for two other men in connection with the girl's Aug 14 death. All four face charges including first-degree murder, human trafficking of a child and procuring a minor for prostitution.

Authorities say the girl overdosed on drugs and was taken to a hospital. A police officer started investigating and called detectives. Since August, police conducted interviews and pulled text messages and video surveillance.

An affidavit says the men used Backpage.com to find clients and drove the girls to meeting locations.

It's not known whether Holman and Santiago-Sotomayor have lawyers.