A fast-moving storm and lake-effect snow have led to school closings and travel troubles in the Northeast.

The latest round of lake-effect storms dumped up to 18 inches near Lake Erie's eastern shore. Blowing snow closed a nearly 60-mile stretch of the westbound lanes of the New York Thruway south of Buffalo on Wednesday.

Meanwhile, scores of business and government closings and delays were in effect across northern New England after the fast-moving system dumped more than a foot of snow.

Thousands of students in New York had Wednesday off.

In southwestern Pennsylvania, icy conditions may have been to blame for a seven-vehicle pileup on Interstate 70.

Officials say whiteout conditions were a factor in a deadly head-on crash south of Buffalo on Tuesday afternoon involving a tractor-trailer and an ambulance.