Anquan Boldin is coming off back-to-back 100-yard games. Ed Szczepanski USA TODAY Sports

Two of the San Francisco 49ers' top offensive players are ailing heading into Thursday night's matchup against the visiting Seattle Seahawks.

Running back Carlos Hyde (foot) and wide receiver Anquan Boldin (hamstring) are both listed as questionable for the game after they were limited in practice against Wednesday. Right tackle Erik Pears is the only other San Francisco player designated as questionable.

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Hyde labored through the second half of Sunday's 25-20 victory over the Baltimore Ravens, rushing for only seven yards on his final seven carries. The 49ers did receive some good news on the injury front when backup running back Reggie Bush was listed as probably after sitting out Sunday with a calf injury.

Boldin rebounded from an ugly two-game stretch by going over 100 yards in each of the last two games, but he appeared to tweak the hamstring late in Sunday's games. He has not missed a game since joining the 49ers at the start of the 2013 season.

The Seahawks have already ruled out five players: defensive tackle Jordan Hill, cornerback Marcus Burley, center Patrick Lewis, linebacker Nick Moody and fullback Derrick Coleman.

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