Ryan Mallett may be without perhaps his most important offensive lineman when he make his debut as Houston's starting quarterback in the Texans' Week 2 matchup against the Carolina Panthers on Sunday.

According the the Houston Chronicle, Texans Pro Bowl left tackle Duane Brown is unlikely to play against the Panthers due to a thumb injury.

Brown injured his thumb during the preseason, but was able to play Week 1 against Kansas City.

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If Brown doesn't play Sunday, the Texans could start Chris Clark at left tackle or move right tackle Derek Newton over to the left side. Clark was acquired in a trade with the Denver Broncos late in the preseason.

(h/t Houston Chronicle)