EAST RUTHERFORD, N.J. (AP) New York Giants rookie Mykkele Thompson will miss the season with an Achilles tendon injury, and fellow safety Landon Collins is sidelined by a sprained knee.

Coach Tom Coughlin announced the injuries on Saturday, leaving his inexperienced safety spot facing major issues.

Thompson and Collins were both hurt in the Giants' preseason opening loss at Cincinnati.

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The Giants moved up in the NFL draft to grab Collins with the first pick of the second round. He was penciled in as a starter almost immediately.

Coughlin does not know how long he will be out with a sprained medial collateral ligament. Thompson, a fifth-round draft pick out of Texas, is done for the year.

That leaves Cooper Taylor, the injured Nat Berhe (calf), converted cornerback Bennett Jackson and veteran Jeromy Miles as the safeties.