Tricia Liston scored 20 points and Duke routed Winthrop 87-45 on Saturday in the first round of the NCAA tournament.
Freshman Oderah Chidom added 17 points for the second-seeded Blue Devils (28-6).
They didn't miss a beat in their first game in nearly two weeks: They never trailed, shot 54 percent and led by double figures for the final 33½ minutes in winning their 21st straight NCAA tournament opener.
In giving the 15th-seeded Eagles (24-9) their worst loss of the season by far, Duke built a 49-23 rebounding advantage and held them to 27 percent shooting — 21 percent in the decisive first half — to advance in the Lincoln Regional bracket.
Big South player of the year Dequesha McClanahan had 22 points to lead Winthrop in its brief first NCAA tournament appearance.