The boy, who was struck by a motorcycle involved in the crash with Odom's car Thursday night, underwent emergency surgery at a nearby hospital in Queens but died on Friday morning, TMZ reported.
Odom, 31, was in Queens to attend the funeral of his cousin and had hired a car service to drive him around. He was riding in the back seat at the time and his reality TV star wife Khloe Kardashian was not in the car.
The car Odom was traveling in reportedly collided with a motorcycle, which in turn struck the 15-year-old pedestrian.
The boy's family told TMZ he sustained major head injuries in the collision.
It was reported that the Lakers forward was particularly upset after the crash took place and was seen crying at the scene.
"My thoughts and prayers are with the young boys family," Odom tweeted late Monday.