A U.S. military drone crashed in northern Syria while carrying out a combat mission against ISIS, the Air Force said Tuesday.

According to a statement, the MQ-9 Reaper drone was not brought down by enemy fire and there were no reports of civilian injuries or damage in the crash.

The statement added that aircraft of the U.S.-led coalition destroyed the crashed drone before it could fall into ISIS hands. An investigation will be conducted to determin the exact cause of the crash.

The Obama administration has often used unmanned aircraft to target leaders of terror groups. On Friday, the White House disclosed that between 64 and 116 civilians had been killed by drone and other airstrikes in Pakistan, Yemen and Africa since Obama took office in 2009.

However, estimates by various human rights groups put the number of civilian deaths in drone strikes over the past seven years as high as 1,100.