Thousands took to the streets Saturday across the United States as demonstrations against President-elect Donald Trump, with many suggesting they would prolong the fight as much as possible to keep him out of office.

In Los Angeles, several thousand people marched through downtown streets Saturday to condemn what they saw as Trump's hate speech about Muslims, pledge to deport people in the country illegally and crude comments about women.

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Jennifer Cruz, 18, of Ventura, California, carried a sign that asked: "Legalize weed but not my Mom?" -- a reference to Californians' Tuesday passage of a measure legalizing recreational marijuana use.

Cruz said her parents have been in the United States illegally for 30 years, although her mother has spent years seeking citizenship. She called the possibility of their deportation terrifying.

"We talk about it almost every day," she said. "My Mom wants to leave it in the hands of God but I'm not just going to sit back and not do anything. I'm going to fight for my parents, even if it kills me."

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Protesters rallied at New York's Union Square before picking up steam and taking their cause toward Trump Tower. Police set up barricades in front of some of the most expensive stores in Manhattan as the group made its way along Fifth Avenue.

"I just can't have Donald Trump running this country and teaching our children racism, sexism and bigotry," said Noemi Abad, 30, a fashion designer, as she marched down the famous road. "Out of his own mouth he made this division. He needs to go -- there's no place for racism in society in America."

The fourth day of protests was mainly peaceful, but in Portland, Oregon, a man who was participating in a march was shot after a confrontation with someone in a vehicle. Police expect the man to survive and detained four people in connection with the shooting early Saturday. A motive for the shooting was unclear. The four people detained are believed to be gang members, but the victim is not.

The shooting followed rowdy Friday night protests, when police used tear gas in response to "burning projectiles" thrown at officers, police said on Twitter. Hundreds of people marched through the city, disrupting traffic and spray-painting graffiti.

Authorities reported instances of vandalism and assault during a rally that organizers had billed as peaceful earlier in the day.

Shawn Smith, 41, of Los Angeles, wore an American flag vest Saturday and held a glittery sign that said "Love Trumps Hate."

"What he's been able to do is make 50 percent of the nation look over their shoulder," he said. "If you're gay, if you're LGBT, if you're Muslim, if you're Latin, if you're special needs, if you're female, it's a much unsafer place now."

Trump supporter Nicolas Quirico was traveling from South Beach to Miami. His car was among hundreds stopped when protesters blocked Interstate 395.

"Trump will be our president. There is no way around that, and the sooner people grasp that, the better off we will be," he said. "There is a difference between a peaceful protest and standing in a major highway backing up traffic for 5 miles. This is wrong."

Protests also were held in Detroit; Minneapolis; Kansas City, Missouri; Olympia, Washington, Iowa City and more.

More than 200 people, carrying signs, gathered on the steps of the Washington state Capitol. The group chanted "not my president" and "no Trump, no KKK, no fascist USA."

In Tennessee, Vanderbilt University students sang civil rights songs and marched through campus across a Nashville street, temporarily blocking traffic.

In Cincinnati, hundreds of protesters had already taken to the streets early Saturday afternoon to peacefully protest the jury's deadlock in the trial of a former white police officer who killed an unarmed black motorist in 2015.

A mistrial was declared in the trial of former University of Cincinnati officer Ray Tensing. He was fired after shooting Sam DuBose in the head after pulling him over for a missing front license plate last year.

Anti-Trump protesters had joined up with trial protesters and marched through downtown.

Demonstrations also took place internationally. A group of Mexicans at statue representing independence in Mexico City expressed their concerns about a possible wave of deportations. One school teacher said it would add to the "unrest" that's already in Mexico. About 300 people protested Trump's election as the next American president outside the U.S. Embassy near the landmark Brandenburg Gate in Berlin.

President Barack Obama meets in Berlin next week with Chancellor Angela Merkel and several other European leaders, and is expected to confront global concerns about Trump's election.

The Associated Press contributed to this report.