When six astronauts launch into orbit on NASA's space shuttle Endeavour Monday, it will be the last liftoff for the well-traveled orbiter.
Endeavour is scheduled to blast off from Launch Pad 39A at NASA's Kennedy Space Center at 8:56 a.m. EDT (1256 GMT). Weather forecasters predict a 70 percent chance of good launch conditions.
This will be the second launch try for Endeavour's STS-134 mission, after a broken set of heaters thwarted an attempt on April 29.
The shuttle will be making its 25th and last flight before retiring to the California Museum of Science in Los Angeles. Its fellow orbiters will also retire to other museums after shuttle Atlantis makes NASA's last-ever space shuttle flight in July. [Photos: Shuttle Endeavour's Final Mission]
"The space shuttle program, I think, will definitely be remembered for the amazing things that it has done," said mission specialist Michael Fincke in a NASA interview. "Everything that we’ve learned along the way, all the technology, all of the science that we’ve been able to bring in in these past years with the space shuttle, I think, is going to be remembered very nicely in the history books."
For Endeavour's mission, commander Mark Kelly will lead a seasoned crew of six on a 16-day trip to the International Space Station. Kelly and Fincke's fellow astronauts include pilot Gregory H. Johnson and mission specialists Greg Chamitoff, Andrew Feustel, and European Space Agency astronaut Roberto Vittori.
Shuttle Endeavour's main payload is a $2 billion astrophysics experiment called the Alpha Magnetic Spectrometer (AMS). The bus-sized device contains a magnet that will search for space particles that could explain cosmic mysteries like dark matter and antimatter. [Q&A With AMS Leader Samuel Ting]
"We’re taking up a very important experiment, the Alpha Magnetic Spectrometer, a science experiment that could change the course of physics," Johnson said in a NASA interview. "It's one of those rare kinds of experiments, that it really might just open some new doors that we never even knew existed."
Endeavour is also carrying up 14,000 pounds (6,350 kilograms) of hardware backups to keep the space station running through at least 2020. The supplies include a new tank of ammonia coolant, equipment for the station's Dextre robot, and spare parts for the laboratory's antenna communications system. [Infographic: How the Alpha Magnetic Spectrometer Will Work]
The astronauts plan four busy spacewalks during the mission to install the new supplies and do maintenance on the exterior of the orbiting outpost.
Endeavour was originally scheduled to blast off April 29, but NASA called off the countdown because of two failed heaters designed to prevent a critical power unit from freezing on orbit. Without functioning heaters, the orbiter's hydraulic systems would have been at risk, officials said.
Engineers worked around the clock to troubleshoot the issue. Ultimately, NASA traced the problem back to a broken switchbox feeding power to the heaters. Workers removed the box and replaced it, and about 20 feet of wiring leading to and from it, with new hardware. Tests have shown the issue to be resolved.
"We have extremely high confidence that the problem is no longer on the ship," Mike Moses, chair of the shuttle's mission management team, said during a press conference last week. [Video: Endeavour's Final Mission]
NASA is expecting large crowds to come out to Florida's Space Coast for the final launch of its youngest orbiter. Around 500,000 spectators are expected, somewhat less than the roughly 750,000 who turned out for the first launch attempt.
NASA officials said the drop was due to the fact that Monday morning is not quite as attractive a time as Friday afternoon for some launch viewers.
President Obama was also on hand for Endeavour's last try at liftoff. When the shuttle didn't launch after all, the president and his family took a tour of the NASA facility. Obama has not announced any plans to come again for take two.
Another high-profile guest will be in attendance, though: Commander Kelly's wife, Congresswoman Gabrielle Giffords, is expected to travel from Houston to Florida to see her husband launch. Giffords has not been seen in public often since she survived a mass shooting in Tucson in January. She has reportedly made great strides in recovering from a bullet wound to the head, and is expected to watch the shuttle lift off with the other astronauts' family members.