Defending champion Brooke Henderson shot a 7-under 65 on Thursday to take a two-stroke lead after the opening round of the LPGA Cambia Portland Classic on Thursday.

Picking up where she left off from a year ago, when Henderson shot a 21-under 267 to win her first LPGA tournament, the 18-year-old Canadian hit 16 greens and made nine birdies on a warm, cloudless day at the 6,476-yard Columbia Edgewater course.

Angela Stanford, Demi Runas and Mariajo Uribe each shot 67 to trail Henderson.

Runas, whose best career finish is a tie for 25th, and Uribe are looking for their first LPGA victories. Stanford lost in a playoff in the 2003 U.S. Women's Open at Pumpkin Ridge, which has previously played host to the Portland Classic. Uribe and Stanford shot bogey-free rounds.