EAST RUTHERFORD, N.J. (AP) Strong side linebacker Devon Kennard and defensive linemen Robert Ayers Jr. and George Selvie are going to miss the New York Giants game Sunday night against the San Francisco 49ers with injuries.

Coach Tom Coughlin ruled out the three players and receiver Victor Cruz on Friday after they did not practice.

Ayers has missed two three straight games with a hamstring injury. Kennard pulled a hamstring last weekend in the win over Buffalo, and Selvie hurt a calf. Cruz has been sidelined all season with a calf injury.

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Linebacker Jonathan Casillas (calf) and backup cornerbacks Jayron Hosley (concussion) and Trumaine McBride (groin) are questionable for the game.

Tight end Jerome Cunningham (knee), tackle Ereck Flowers (ankle) and defensive tackle Markus Kuhn (knee) all practiced and are probable.

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AP NFL website: www.pro32.ap.org and www.twitter.com/AP-NFL