C.J. Fair scored 22 points and No. 7 Syracuse closed the regular season with a 74-58 victory in the program's first trip to Florida State.
The Orange, who ended a two-game losing streak, had lost 4 of 5 after starting the season 25-0.
Jerami Grant, who had been bothered by back problems recently, had 16 points and eight rebounds while Tyler Ennis finished with 16 points for Syracuse (27-4, 14-4 Atlantic Coast Conference).
Okaro White led Florida State with 20 points and 10 rebounds. Fellow senior Ian Miller scored 16 points in his last home game while Aaron Thomas chipped in 14.
The bubble may have burst for Florida State (18-12, 9-9) which desperately needed a signature win at this point of the season to earn a berth in the NCAA tournament.