Gabe York scored 20 points, Nick Johnson added 16 and No. 5 Arizona crushed Fairleigh Dickinson 100-50 to open the NIT Season Tip-Off on Monday night.
Arizona (4-0) allowed the Knights to stay close early before blowing open the game with runs of 18-3 and 18-2 in the first half, keyed by Rondae Hollis-Jefferson and T.J. McConnell.
Hollis-Jefferson finished with 13 points, McConnell had nine assists with one turnover and Arizona shot 54 percent to help Sean Miller become the fifth coach to win 100 games in Tucson.
The Wildcats move on to face Rhode Island on Tuesday night with a trip to Madison Square Garden on the line.
Sidney Sanders Jr. had 16 points to lead Fairleigh Dickinson (1-3), which shot 31 percent.