A 24-year-old, Wood had appeared in five consecutive games -- four relief outings and one start -- since last allowing a run during a 5-3 loss to the New York Yankees on June 20 in Cincinnati.
He's 1-0 in his outings since, picking up the win after two-thirds of an inning of relief against the Pirates during Cincinnati's 11-8 victory in Pittsburgh on Aug. 19.
Overall, he's pitched 10 consecutive shutout innings while allowing five hits and striking out nine batters.
He's 2-1 lifetime against the Pirates with a 4.91 earned run average in 11 innings.
In Friday's opener, pinch-hitter Ryan Ludwick posted the game-winning hit in the bottom of the ninth inning, sending the Pirates to a 4-3 win.
Pinch-hitter Jason Jaramillo ripped a double to left with one out off Reds reliever Bill Bray (5-3) before Ludwick came through with the walk-off single to center against Nick Masset, allowing pinch-runner Chase d'Arnaud to easily score from second.
Joel Hanrahan (1-4) earned the win despite plunking Todd Frazier to force in the tying run in the top half of the frame.
"I didn't have all my good stuff, but I tried to find a way to make it work," Hanrahan said. "I think I hit my first guy of the year. This game's funny."
The Pirates start 26-year-old righty Brad Lincoln, who appears for the second time in his career against the Reds.
Lincoln took a no-decision in the initial outing, tossing two-thirds of an inning in relief in the aforementioned 11-8 game in which Wood got the victory.
He's made six starts since and is 1-3 while allowing 17 runs in 31 innings.
Lincoln is 0-2 in seven home appearances this season.
Pittsburgh is 9-4 versus the Reds this season.