Ryan Reynolds is destined to be surrounded by women.

After accidentally revealing the gender of his second child with wife, Blake Lively, on Twitter, the "Deadpool" star, 40, confirmed that the couple recently welcomed a second baby girl.

WATCH: Ryan Reynolds Might Have Just Revealed the Sex of Second Child With Blake Lively

"Two under two is tough!" he admitted to Conan O'Brien on Wednesday night. "Lot of estrogen. It feels like an American Girl Doll just took a s--t on my life. I'll pour some cereal in the morning and there's like a tiny shoe in there. That's a choking hazard for me!"

The proud dad also quipped about not favoring one child over the other, saying, "It's pretty remarkable, you know? I used to say to my wife all the time, 'I can't actually imagine ever loving a second child as much as I love the first.' Then, that baby comes popping out and I acted like I was totally wrong."

The actor veered away from his personal life to play a game with the audience, in which they had to guess what he was there to promote. After a few ridiculous suggestions, a line of ham underwear and Reynolds Wrap aluminum foil, he brought up his new film "The Notebook 2" starring Ryan Reynolds and Conan McAdams.

"Remember that vacation we took in Tijuana a few years ago?" Reynolds asked the host. "We split that bottle of absinthe? Well, we fell in love, and I filmed it."

WATCH: Blake Lively Sends the Cutest 40th Birthday Message to Ryan Reynolds -- See Her Sweet Post!

In the clip from the fake film, Reynolds and O'Brien acted out the classic rain scene that was previously done by Ryan Gosling and Rachel McAdams in the 2004 romance. When it came time for the two jokesters to kiss, they really went all-out, grabbing each other's faces and making out for quite a while.