The older brother of a Syrian boy whose dazed and bloodied face stunned the world has died from wounds sustained in the same bombardment that injured his sibling, observers said Saturday. 

Reuters, citing the U.K.-based Syrian Observatory for Human Rights, reported that 10-year-old Ali Daqneesh suffered from internal bleeding and organ damage after Wednesday's airstrike in the city of Aleppo.

Ali's five-year-old brother, Omran Daqneesh. was rescued from the rubble of a missile-struck building. A photo of him sitting alone in an ambulance, confused and covered in debris and blood, has become the haunting image of the unforgiving struggle for the city. 

In August, the International Committee for the Red Cross called the battle for Aleppo "one of the most devastating conflicts in modern times."

The Observatory says that fighting and airstrikes in and around Aleppo has killed 448 civilians so far this month, according to Reuters. The airstrikes have largely targeted the east of the city, which is held by rebels who have been fighting since 2011 to oust Syrian President Bashar al-Assad.

Pro-government forces, supported by overwhelming Russian air power, had managed to encircle rebels and some 300,000 civilians in the city's eastern quarters in July, leading the U.N. to raise the concerns of catastrophic suffering if a protracted siege ensued.

But a fierce offensive led by thousands of rebels from outside the city broke the blockade on July 31, and fighting has only intensified since then. Both sides are bombarding their opponents indiscriminately, at a tremendous cost to infrastructure and human life.

The main Kurdish militia, known as the People's Protection Units, or YPG, controls several predominantly Kurdish northern neighborhoods.

The main insurgent groups in the city are the Nour el-Din Zenki brigade; the ultraconservative Ahrar al-Sham group; and the Al-Qaeda linked Jabhat Fatah al-Sham, formerly known as the Nusra Front.

The Associated Press contributed to this report.

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